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Antikörper

Anti-Human CD294 PE MAb (Clone :BM16)

Produktgrößen
100 tests
£620,00
30-2852-100TESTS
Über dieses Produkt
SKU:
30-2852
Zusätzliche Namen:
DP2; PTGDR2; DL1R; CRTH2; GPR44
translate.label.attr.clone:
BM16
Klonalität:
Monoclonal
Konjugat:
PE
Weitere Details:
Specificity: The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2); a G-protein-coupled seven-transmembrane protein expressed on Th2 cells; peripheral blood basophils and eosinophils. CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells; but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils; basophils; and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut; heart; and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.
Host:
Rat
Immunogen:
Human CD294 transfected rat cell line TART/B19-12.10
Isotyp:
Rat IgG2a
Aufreinigung:
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Flow cytometry multicolor surface staining of human gated lymphocytes and basophils stained using anti-human CD3 (UCHT1) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD294 (BM16) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD294 positive basophils (red-filled) from CD3 positive CD294 negative T cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD294 (BM16) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD294 positive basophils (red-filled) from CD3 positive CD294 negative T cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD294 (BM16) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).