Anti-Human CD43 APC MAb (Clone: MEM-59)
Produktgrößen
100 tests
£620,00
30-2846-100TESTS
Über dieses Produkt
- SKU:
- 30-2846
- Zusätzliche Namen:
- Leukosialin; Sialophorin; Galactoglycoprotein; GALGP; LSN; SPN; GALGP; GP5
- translate.label.attr.clone:
- MEM-59
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- Specificity: The antibody MEM-59 recognizes a neuraminidase-sensitive extracellular epitope on CD43 (Leukosialin); a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocytes; it is negative on resting B lymphocytes and erythrocytes. CD43 (leukosialin; sialophorin) is a transmembrane mucin-like protein with high negative charge; expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion; however; in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein; but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
- Host:
- Mouse
- Immunogen:
- Human T lymphocytes.
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
