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Antikörper

Anti-Human IL-17A MAb (Clone: 9F9)

Produktgrößen
0.1 mg
£562,00
30-2837-0.1MG
Über dieses Produkt
SKU:
30-2837
Zusätzliche Namen:
Interleukin 17; Interleukin 17A; IL17A; Anti-Hu IL-17A Purified
translate.label.attr.clone:
9F9
Klonalität:
Monoclonal
Weitere Details:
Specificity: The mouse monoclonal antibody 9F9 recognizes human interleukin 17A (IL-17A; secreted or intracellular). Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules; chemokines; antimicrobial peptides; and remodeling proteins. It plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. It is the signature effector cytokine of Th17 cells; and in this role it primarily induces neutrophil activation and recruitment at infection and inflammatory sites. High levels of IL-17A are associated with rheumatoid arthritis; psoriasis; multiple sclerosis; and another inflammatory diseases; including lung injugy during severe COVID 19. This cytokine also contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13; enhancing retention of B cells within the germinal centers; B cell somatic hypermutation rate and selection toward plasma cells. It is an effector cytokine for invariant NKT cells (iNKT); and it is involved in epithelial barrier formation upon injury.
Format:
Purified
Host:
Mouse
Immunogen:
Mammalian-derived human IL-17-IgG fusion protein; boost with recombinant human IL-17A
Isotyp:
Mouse IgG1 kappa
Aufreinigung:
Purified by protein-A affinity chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2: Flow cytometry multicolor intracellular staining of PHA stimulated and Brefeldin A treated peripheral whole blood showing lymphocytes stained using anti-human CD4 (MEM-241) PE-Cy7 antibody (4 μl reagent / 100 μl of peripheral whole blood) and anti-human IL-17A (9F9) purified antibody (concentration in sample 0;5 μg/ml; GAM APC).
Fig 3: Separation of human CD4 positive IL-17A positive lymphocytes (red-filled) from CD4 negative IL-17A negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human PHA stimulated and Brefeldin A treated peripheral whole blood stained using anti-human IL-17A (9F9) purified antibody (concentration in sample 0;5 μg/ml; GAM APC).
Fig 3: Separation of human CD4 positive IL-17A positive lymphocytes (red-filled) from CD4 negative IL-17A negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human PHA stimulated and Brefeldin A treated peripheral whole blood stained using anti-human IL-17A (9F9) purified antibody (concentration in sample 0;5 μg/ml; GAM APC).