Anti-Hu CD33 PE
Produktgrößen
100 Tests
£620,00
30-2791-100TESTS
Über dieses Produkt
- SKU:
- 30-2791
- Zusätzliche Namen:
- CD33 molecule SIGLEC3; p67
- translate.label.attr.clone:
- WM53
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage; binds sialic acid residues in N- and O-glycans on cell surfaces; and is a therapeutic target for acute myeloid leukemia.Specificity :The mouse monoclonal antibody WM53 reacts with an extracellular epitope of CD33; a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors; monocytes; granulocytes; dendritic cells and mast cells; it is absent on platelets; lymphocytes; erythrocytes and hematopoietic stem cells.
- Immunogen:
- Human AML cells
- Aufreinigung:
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php