Anti-p53 Purified
Produktgrößen
0.1 mg
£541,00
30-2725-0.1MG
Über dieses Produkt
- SKU:
- 30-2725
- Zusätzliche Namen:
- tumor protein p53 BCC7; TRP53; TP53; LFS1
- translate.label.attr.clone:
- BP53-12
- Klonalität:
- Monoclonal
- Weitere Details:
- The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes; resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest; or proteins that trigger apoptosis; such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain; central DNA-binding domain; oligomerisation domain; and C-terminal regulatory domain. There are various phosphorylation sites on p53; of which the phosphorylation at Ser15 is important for p53 activation and stabilization. Specificity :The antibody BP53-12 recognizes a defined epitope (aa 16-25) on human p53; a 50 kDa intracellular tumour suppressor found in increased amounts in a wide variety of transformed cells; it is frequently mutated or inactivated in many types of cancer.
- Format:
- Purified
- Immunogen:
- Bacterially expressed full-length wild-type p53
- Aufreinigung:
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php