Anti-Human CD243 APC (Clone : UIC2)
Produktgrößen
100 tests
£620,00
30-2614-100TESTS
Über dieses Produkt
- SKU:
- 30-2614
- Zusätzliche Namen:
- P-Glycoprotein; CLCS; MDR1; PGY1; ABC20; GP170; ABCB1; ABC transporter;ATP binding cassette subfamily B member 1
- translate.label.attr.clone:
- UIC2
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- CD243; also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate Specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues; including the brain; liver; pancreas; testes; kidney; and blood (B; T; NK cells; but not monocytes).Specificity : The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1); an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells; B; T; and NK cells; or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate.
- Immunogen:
- NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
- Isotyp:
- Mouse IgG2a kappa
- Aufreinigung:
- The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
