Anti-Human CD42b APC (Clone : AK2)
Produktgrößen
100 tests
£620,00
30-2565-100TESTS
Über dieses Produkt
- SKU:
- 30-2565
- Zusätzliche Namen:
- BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3;glycoprotein Ib platelet subunit alpha
- translate.label.attr.clone:
- AK2
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- CD42b (GPIb alpha) composes together with GPIb beta; GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury; as well as to thrombin; coagulation factors XI and XII; high molecular weight kininogen; TSP-1; integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.Specificity : The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha); a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
- Immunogen:
- Human platelets
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
