Anti-Rat CD8a Low Endotoxin Antibody (Clone : OX-8)
Produktgrößen
0.1 mg
£532,00
30-2544-0.1MG
Über dieses Produkt
- SKU:
- 30-2544
- Zusätzliche Namen:
- Ly-2; Ly-B; Ly-35; Lyt-2;CD8a molecule
- translate.label.attr.clone:
- OX-8
- Klonalität:
- Monoclonal
- Weitere Details:
- The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells; intraepithelial lymphocytes; NK cells; macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling. Specificity : The mouse monoclonal antibody OX-8 recognizes the hinge-like membrane-proximal extracellular domain of rat CD8a (32-34 kDa; alpha chain of the CD8 antigen).
- Format:
- Low Endotoxin
- Immunogen:
- High Mw glycoproteins from rat thymocytes
- Isotyp:
- Mouse IgG1 kappa
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies
- Datenblatt des Herstellers:download_pdf.php