PE Conjugated; Anti-ARHGEF4 / ASEF1 Monoclonal Antibody (Clone:ARHGEF-08)
Produktgrößen
0.1 mg
£620,00
30-2355-0.1MG
Über dieses Produkt
- SKU:
- 30-2355
- Zusätzliche Namen:
- ARHGEF4||KIAA1112
- translate.label.attr.clone:
- ARHGEF-08
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- ARHGEF4 (Rho guanine nucleotide exchange factor 4); also known as ASEF 1 (adenomatous polyposis coli - stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH); Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain; whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42; which leads to decreased cell-cell adherence and enhanced cell migration.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human ARHGEF4 (amino acids 143-271)
- Isotyp:
- Mouse IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg