PE Conjugated Anti-RLTPR / CARMIL2 Monoclonal Antibody (Clone:EM-53)
Produktgrößen
0.1 mg
£738,00
30-2353-0.1MG
Über dieses Produkt
- SKU:
- 30-2353
- Zusätzliche Namen:
- CARMIL2||LRRC16C||RLTPR
- translate.label.attr.clone:
- EM-53
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- RLTPR / CARMIL2 (RGD motif; leucine rich repeats; tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2); also known as LRRC16C; is a cytosolic protein; which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends. RLTPR / CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2; however; seems unable to nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR / CARMIL2 is crutial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function. The lack of functional RLTPR / CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency. Expression of RLTPR / CARMIL2 was also detected in human and murine B cells; but it seems not to be involved in BCR-mediated signaling.
- Host:
- Mouse
- Immunogen:
- Murine Rltpr (amino acids 1147-1397)
- Isotyp:
- Mouse IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg