PE Conjugated; Anti-GCPII / PSMA Monoclonal Antibody (Clone:GCP-05)
Produktgrößen
0.1 mg
£730,00
30-2258-0.1MG
Über dieses Produkt
- SKU:
- 30-2258
- Zusätzliche Namen:
- FOLH1||FOLH||NAALAD1||PSM||PSMA||GIG27
- translate.label.attr.clone:
- GCP-05
- Klonalität:
- Monoclonal
- Konjugat:
- PE
- Weitere Details:
- Glutamate carboxypeptidase II (GCPII); also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I); folate hydrolase (FOLH1); and prostate-specific membrane antigen (PSMA); is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate; which is released from neurons in a calcium-dependent manner; to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic; GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease; Huntington´s disease; epilepsy; schizophrenia; stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate; enabling folate to be absorbed by gastrointestinal tract. GCPII; which is present in a number of tissues at low levels; is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII; and this ratio is reversed upon malignant transformation.
- Host:
- Mouse
- Immunogen:
- amino acids 44-750 of human GCPII
- Isotyp:
- Mouse IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
