Alexa Fluor 488 Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-226)
Produktgrößen
100 tests
£649,00
30-2196AF488-100TESTS
Über dieses Produkt
- SKU:
- 30-2196AF488
- Zusätzliche Namen:
- ENG||END||Endoglin||HHT1||ORW1
- translate.label.attr.clone:
- MEM-226
- Klonalität:
- Monoclonal
- Weitere Details:
- CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing; infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. Specificity: The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin); a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels); activated monocytes and tissue macrophages; stromal cells of certain tissues including bone marrow; pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
- Host:
- Mouse
- Immunogen:
- Recombinant Vaccinia virus containing the human CD105 cDNA.
- Isotyp:
- Mouse IgG2a
- Aufreinigung:
- Purified antibody is conjugated with Alexa Fluor 488 NHS ester under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg