Anti-CD4 Monoclonal Antibody (Clone:OX-35)-FITC Conjugated
Produktgrößen
0.1 mg
£561,00
30-2091-0.1MG
Über dieses Produkt
- SKU:
- 30-2091
- Zusätzliche Namen:
- Cd4
- translate.label.attr.clone:
- OX-35
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck; a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands; such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation; T/B-cell adhesion; T-cell differenciation; T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood; tissue and organs (SCID immunodeficiency).
- Host:
- Mouse
- Immunogen:
- MLR generated rat Th cells
- Isotyp:
- Mouse IgG2a
- Reaktivitäten:
- Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg