Anti-CD5 Monoclonal Antibody (Clone:CRIS1)-FITC Conjugated
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100 tests
£581,00
30-2016-100TESTS
Über dieses Produkt
- SKU:
- 30-2016
- Zusätzliche Namen:
- CD5||LEU1
- translate.label.attr.clone:
- CRIS1
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes; most of thymocytes; subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization; tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70; p56lck; p59fyn; PC-PLC; etc. CD5 may serve as a dual receptor; giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals; in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL; Hairy cell leukemia; etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis; etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
- Host:
- Mouse
- Immunogen:
- stimulated human leukocytes
- Isotyp:
- Mouse IgG2a
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php