Anti-CD30 / Ki-1 Monoclonal Antibody (Clone:MEM-268)-FITC Conjugated
Produktgrößen
100 tests
£595,00
30-2013-100TESTS
Über dieses Produkt
- SKU:
- 30-2013
- Zusätzliche Namen:
- TNFRSF8||CD30||D1S166E
- translate.label.attr.clone:
- MEM-268
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation; activation; differentiation; and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells; CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas); virus-infected T and B cells; and on normal T and B cells after activation. In T cells; CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.
- Host:
- Mouse
- Immunogen:
- Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
- Isotyp:
- Mouse IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:30-2013.jpeg