Anti-CD20 Monoclonal Antibody (Clone:LT20)-Biotin Conjugated
Produktgrößen
0.1 mg
£581,00
30-1881-0.1MG
Über dieses Produkt
- SKU:
- 30-1881
- Zusätzliche Namen:
- MS4A1||CD20
- translate.label.attr.clone:
- LT20
- Klonalität:
- Monoclonal
- Konjugat:
- Biotin
- Weitere Details:
- CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells; but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel); cell cycle progression and B-cell proliferation. It is associated with lipid rafts; but the intensity of this association depends on extracellular triggering; employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation; BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis; whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells; as it is expressed at high levels on most B-cell malignancies; but does not become internalized or shed from the plasma membrane following mAb treatment.
- Host:
- Mouse
- Immunogen:
- Normal human lymphocytes from lymph node.
- Isotyp:
- Mouse IgG2a
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php