Anti-CD8 Monoclonal Antibody (Clone:MEM-31)-Biotin Conjugated
Produktgrößen
0.1 mg
£581,00
30-1834-0.1MG
Über dieses Produkt
- SKU:
- 30-1834
- Zusätzliche Namen:
- T-lymphocyte differentiation antigen T8/Leu-2; CD8a; MAL
- translate.label.attr.clone:
- MEM-31
- Klonalität:
- Monoclonal
- Konjugat:
- Biotin
- Weitere Details:
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells; intraepithelial lymphocytes; NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.
- Host:
- Mouse
- Immunogen:
- Crude thymus membrane fraction.
- Isotyp:
- Mouse IgG2a
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg