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Antikörper

APC Conjugated Anti-CD79a Monoclonal Antibody (Clone:HM47)

Produktgrößen
100 tests
£620,00
30-1815-100TESTS
Über dieses Produkt
SKU:
30-1815
Zusätzliche Namen:
CD79A||IGA||MB1
translate.label.attr.clone:
HM47
Klonalität:
Monoclonal
Konjugat:
APC
Weitere Details:
CD79a (Ig alpha; MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs); and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently; in pre-B cells; CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage; CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn; which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Host:
Mouse
Immunogen:
Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
Isotyp:
Mouse IgG1
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Flow cytometry multicolor surface staining pattern of human lymfocytes stained using anti-human CD19 (LT19) PE antibody (20 μl reagent / 100 μl of peripheral whole blood) and intracellular staining pattern using anti-human CD79a (HM47) APC antibody (concentration in sample 1 μg/ml).
Figure 3: Separation of human CD79a positive CD19 positive B cells (red-filled) from CD79a negative CD19 negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) APC antibody (concentration in sample 1 μg/ml).
Figure 3: Separation of human CD79a positive CD19 positive B cells (red-filled) from CD79a negative CD19 negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) APC antibody (concentration in sample 1 μg/ml).