Anti-CD45 / LCA Monoclonal Antibody (Clone:MEM-28)-APC Conjugated
Produktgrößen
100 tests
£620,00
30-1693-100TESTS
Über dieses Produkt
- SKU:
- 30-1693
- Zusätzliche Namen:
- PTPRC||CD45
- translate.label.attr.clone:
- MEM-28
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells; comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling; serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains; whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling; CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
- Host:
- Mouse
- Immunogen:
- Human thymocytes and T lymphocytes.
- Isotyp:
- Mouse IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg