APC Conjugated; Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:MEM-25)
Produktgrößen
100 tests
£620,00
30-1685-100TESTS
Über dieses Produkt
- SKU:
- 30-1685
- Zusätzliche Namen:
- ITGAL||CD11A
- translate.label.attr.clone:
- MEM-25
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1); the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation; which supports tight binding of LFA-1 to its ligands; the intercellular adhesion molecules ICAM-1; -2; -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement; but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example; humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
- Host:
- Mouse
- Immunogen:
- Leukocytes from a pacient suffering from a LGL-type leukaemia.
- Isotyp:
- Mouse IgG1
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg