Anti-CD43 / Leukosialin Monoclonal Antibody (Clone:MEM-59)-Low Endotoxin
Produktgrößen
0.1 mg
£541,00
30-1600-0.1MG
Über dieses Produkt
- SKU:
- 30-1600
- Zusätzliche Namen:
- SPN||CD43
- translate.label.attr.clone:
- MEM-59
- Klonalität:
- Monoclonal
- Weitere Details:
- CD43 (leukosialin; sialophorin) is a transmembrane mucin-like protein with high negative charge; expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion; however; in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein; but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
- Format:
- Low Endotoxin
- Host:
- Mouse
- Immunogen:
- Human T lymphocytes.
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
