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Antikörper

PE-Cy7 Conjugated Anti-CD154 / CD40L Monoclonal Antibody (Clone: 24-31)

Produktgrößen
100TESTS
£760,00
30-1564PE-Cy7-100TESTS
Über dieses Produkt
SKU:
30-1564PE-Cy7
Zusätzliche Namen:
CD40LG||CD40L||TNFSF5||TRAP||T-BAM||Ly62||gp39
translate.label.attr.clone:
24-31
Klonalität:
Monoclonal
Weitere Details:
CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family; and is expressed primarily on activated CD4+ lymphocytes; but also on mast cells; basophils; eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells; including dendritic cells; macrophages; and B cells; and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.
Format:
Purified
Host:
Mouse
Immunogen:
human CD154 fusion protein
Isotyp:
Mouse IgG1
Aufreinigung:
Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion c
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C protected from light. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
Figure 2: Flow cytometry multicolor surface staining pattern of human stimulated (PMA + Ionomycin) lymphocytes stained using anti-human CD3 (UCHT1) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD154 (24-31) PE-Cy7 antibody (4 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD154 positive CD3 positive T cells (red-filled) from CD154 negative CD3 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated (PMA + Ionomycin) peripheral blood mononuclear cells stained using anti-human CD154 (24-31) PE-Cy7 antibody (4 μl reagent / 100 μl of peripheral whole blood).
Figure 3: Separation of human CD154 positive CD3 positive T cells (red-filled) from CD154 negative CD3 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated (PMA + Ionomycin) peripheral blood mononuclear cells stained using anti-human CD154 (24-31) PE-Cy7 antibody (4 μl reagent / 100 μl of peripheral whole blood).