Anti-EGFR Monoclonal Antibody (Clone:EGFR1) Purified
Produktgrößen
0.1 mg
£570,00
30-1484-0.1MG
Über dieses Produkt
- SKU:
- 30-1484
- Zusätzliche Namen:
- EGFR||ERBB||ERBB1||HER1
- translate.label.attr.clone:
- EGFR1
- Klonalität:
- Monoclonal
- Weitere Details:
- The oncoprotein EGFR (epidermal growth factor receptor); also known as HER1 / ErbB1; is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis; although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human epidermoid carcinoma line A431
- Isotyp:
- Mouse IgG2b
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:30-1484.jpg
