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Antikörper

Anti-EGFR (Phospho-Tyr992) Monoclonal Antibody (Clone:EM-12)

Produktgrößen
0.1 mg
£581,00
30-1399-0.1MG
Über dieses Produkt
SKU:
30-1399
Zusätzliche Namen:
EGFR||ERBB||ERBB1||HER1
translate.label.attr.clone:
EM-12
Klonalität:
Monoclonal
Weitere Details:
The oncoprotein EGFR (epidermal growth factor receptor); also known as HER1 / ErbB1; is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis; although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Format:
Purified
Host:
Mouse
Immunogen:
Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR.
Isotyp:
Mouse IgG1
Aufreinigung:
Purified by protein-A affinity chromatography
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Immunoprecipitation of EGFR from EGF-treated A431 cells by monoclonal antibodies EM-12 (A); EM-13 (B); a commercial anti-EGFR polyclonal antibody (C) and anti-EGFR monoclonal mAb108 (D). The precipitates were immunoblotted with EM-12 or EM-13 antibody; and goat anti-mouse-HRP.
Figure 3: Immunoprecipitation of EGFR from EGF-treated A431 cells by phosphospecific monoclonal antibodies EM-12 (A); EM-13 (B); a commercial anti-EGFR polyclonal antibody (C) and anti-EGFR monoclonal mAb108 (D). The precipitates were immunoblotted with a commercial anti-EGFR polyclonal and goat anti-rabbit-HRP.
Figure 3: Immunoprecipitation of EGFR from EGF-treated A431 cells by phosphospecific monoclonal antibodies EM-12 (A); EM-13 (B); a commercial anti-EGFR polyclonal antibody (C) and anti-EGFR monoclonal mAb108 (D). The precipitates were immunoblotted with a commercial anti-EGFR polyclonal and goat anti-rabbit-HRP.