Anti-CD45 Monoclonal Antibody (Clone:EM-05)
Produktgrößen
0.1 mg
£482,00
30-1386-0.1MG
Über dieses Produkt
- SKU:
- 30-1386
- Zusätzliche Namen:
- Ptprc||Ly-5
- translate.label.attr.clone:
- EM-05
- Klonalität:
- Monoclonal
- Weitere Details:
- CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells; comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling; serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains; whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling; CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
- Format:
- Purified
- Host:
- Rat
- Immunogen:
- Murine peripheral blood leukocytes
- Isotyp:
- Rat IgG
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php