Anti-AHNAK1 Monoclonal Antibody (Clone:EM-09)
Produktgrößen
0.1 mg
£581,00
30-1377-0.1MG
Über dieses Produkt
- SKU:
- 30-1377
- translate.label.attr.clone:
- EM-09
- Klonalität:
- Monoclonal
- Weitere Details:
- AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane; connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells; AHNAK1 is localized in cytoplasm or is membrane-associated; but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Bacterially expressed fragment of N-terminal domain of human AHNAK1.
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
