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Antikörper

Anti-GCPII / PSMA Monoclonal Antibody (Clone:GCP-04)

Produktgrößen
0.1 mg
£591,00
30-1370-0.1MG
Über dieses Produkt
SKU:
30-1370
Zusätzliche Namen:
FOLH1||FOLH||NAALAD1||PSM||PSMA||GIG27
translate.label.attr.clone:
GCP-04
Klonalität:
Monoclonal
Weitere Details:
Glutamate carboxypeptidase II (GCPII); also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I); folate hydrolase (FOLH1); and prostate-specific membrane antigen (PSMA); is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate; which is released from neurons in a calcium-dependent manner; to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic; GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease; Huntington´s disease; epilepsy; schizophrenia; stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate; enabling folate to be absorbed by gastrointestinal tract. GCPII; which is present in a number of tissues at low levels; is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII; and this ratio is reversed upon malignant transformation.
Format:
Purified
Host:
Mouse
Immunogen:
Recombinant fragment of human GCPII (amino acids 44-750) produced in S2 cells
Isotyp:
Mouse IgG1
Aufreinigung:
Purified by protein-A affinity chromatography
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Immunohistochemistry of GCPII in human Medulla oblongata by GCP-04 monoclonal antibody. Mag. 40x; positive astrocytes in white matter.
Figure 3: Immunohistochemistry of GCPII in human prostate by GCP-04 monoclonal antibody. Mag. 400x; positive epithelium of the prostate glands.
Figure 4: Western blotting analysis of human PSMA using mouse monoclonal antibody GCP-04 on lysates of LNCaP cell line and Jurkat cell line (PSMA non-expressing cell line; negative control) under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-PSMA monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody.
Figure 4: Western blotting analysis of human PSMA using mouse monoclonal antibody GCP-04 on lysates of LNCaP cell line and Jurkat cell line (PSMA non-expressing cell line; negative control) under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-PSMA monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody.