Anti-ZAP-70 Monoclonal Antibody (Clone:ZAP-03)
Produktgrößen
0.1 mg
£551,00
30-1342-0.1MG
Über dieses Produkt
- SKU:
- 30-1342
- Zusätzliche Namen:
- ZAP70||SRK
- translate.label.attr.clone:
- ZAP-03
- Klonalität:
- Monoclonal
- Weitere Details:
- The ZAP-70 (zeta-associated protein of 70 kDa) tyrosine kinase was identified as a tyrosine phosphoprotein that associates with TCR zeta subunit and undergoes tyrosine phosphorylation following TCR stimulation. ZAP-70 is a Syk family tyrosine kinase primarily expressed in T and NK cells that plays an essential role in signaling through the TCR. TCR-mediated activation of T cells is crucial to the immune response. In humans; ZAP-70 gene mutations resulting in lower ZAP-70 protein expression levels or expression of catalytically inactive ZAP-70 proteins; have been identified. ZAP-70 deficiency results in the absence of mature CD8+ T cells and the prevention of TCR-mediated activation of CD4+ T cells; and it can lead to severe combined immunodeficiency.In patients with chronic lymphocytic leukemia (B-CLL); ZAP-70 expression on B cell was shown to be correlated with disease progression and survival. ZAP-70 contains two N-terminal SH2 domains (Src homology domain 2) and a C-terminal kinase domain. During T cell activation; the binding of ZAP-70 SH2 domains to the phosphorylated zeta subunit on the activated TCR complex causes a colocalization with the Lck tyrosine kinase that phosphorylates ZAP-70 on Tyr493 in the activation loop. ZAP-70 autophosphorylates multiple tyrosines in the region between the SH2 domains and the kinase domain; including the binding sites for additional SH2-containing signaling proteins such as SLP76; LAT; Lck; PLCgamma1; Vav; Shc; Ras-GAP; and Abl. ZAP-70-mediated activation of these downstream effectors leads to the release of intracellular calcium stores; and the transcription of interleukin-2 and other genes important for an immune response.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Bacterially expressed fusion protein representing C-terminal part (160 amino acids) of human ZAP-70 with histidine tag
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
