Anti-PAG / Cbp Polyclonal Antibody
Produktgrößen
0.1 mg
£581,00
30-1280-0.1MG
Über dieses Produkt
- SKU:
- 30-1280
- Zusätzliche Namen:
- PAG1||CBP||PAG
- Klonalität:
- Polyclonal
- Weitere Details:
- PAG (phosphoprotein associated with GEMs); also known as Cbp (Csk-binding protein); is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains); which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases; PAG binds and thereby activates the protein tyrosine kinase Csk; the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding; while T cell receptor signaling causes PAG dephosphorylation; loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
- Isotyp:
- Rabbit IgG
- Aufreinigung:
- Purified from rabbit serum by precipitation methods
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:download_pdf.php