Anti-SLP76 Monoclonal Antibody (Clone:SLP-76/03)
Produktgrößen
0.1 mg
£581,00
30-1275-0.1MG
Über dieses Produkt
- SKU:
- 30-1275
- Zusätzliche Namen:
- LCP2
- translate.label.attr.clone:
- SLP-76/03
- Klonalität:
- Monoclonal
- Weitere Details:
- SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells; mast cells; neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2; SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
- Isotyp:
- Mouse IgG2b
- Aufreinigung:
- Purified by protein-G affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg