Anti-STAT1 Monoclonal Antibody (Clone:SM1)
Produktgrößen
0.1 mg
£581,00
30-1247-0.1MG
Über dieses Produkt
- SKU:
- 30-1247
- Zusätzliche Namen:
- STAT1
- translate.label.attr.clone:
- SM1
- Klonalität:
- Monoclonal
- Weitere Details:
- STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest; apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2; dimerizes; translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway; independently of tyrosine phosphorylation. However; the both modifications are important for its maximal transcriptional activity. On the other hand; STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- STAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).
- Isotyp:
- Mouse IgG2b
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
