Anti-CD18 / Integrin beta2 subunit Monoclonal Antibody (Clone:MEM-148)
Produktgrößen
0.1 mg
£551,00
30-1218-0.1MG
Über dieses Produkt
- SKU:
- 30-1218
- Zusätzliche Namen:
- ITGB2||CD18||MFI7
- translate.label.attr.clone:
- MEM-148
- Klonalität:
- Monoclonal
- Weitere Details:
- CD18; integrin beta2 subunit; forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18; LFA-1); alphaMbeta2 (CD11b/CD18; Mac-1; CR3); alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases; the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration; mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Peripheral blood mononuclear cells
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
