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Antikörper

Alexa Fluor 700 conjugated Anti-CD34 / Mucosialin Monoclonal Antibody (Clone:4H11[APG])

Produktgrößen
100 tests
£649,00
30-1185AF700-100TESTS
Über dieses Produkt
SKU:
30-1185AF700
Zusätzliche Namen:
CD34;HLDA VI: WS Code M MA58
translate.label.attr.clone:
4H11[APG]
Klonalität:
Monoclonal
Weitere Details:
CD34 is a highly glycosylated monomeric 111-115 kDa surface protein; which is present on many stem cell populations. It is a well established stem cell marker; though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion; differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. Specificity: The mouse monoclonal antibody 4H11[APG] reacts with extracellular class III epitope on CD34; a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody 4H11[APG] completely blocks binding of class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
Host:
Mouse
Immunogen:
Permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.
Isotyp:
Mouse IgG1
Aufreinigung:
Purified antibody is conjugated with Alexa Fluor 700 NHS ester under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure-2: Separation of human CD34 positive stem cells (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD34 (4H11[APG]) Alexa Fluor 700 antibody (4 µl reagent / 100 µl of peripheral whole blood).
Figure-3: Flow cytometry surface staining pattern of human peripheral whole blood showing CD34 positive stem cells (red) stained using anti-human CD34 (4H11[APG]) Alexa Fluor 700 antibody (4 µl reagent / 100 µl of peripheral whole blood).
Figure-3: Flow cytometry surface staining pattern of human peripheral whole blood showing CD34 positive stem cells (red) stained using anti-human CD34 (4H11[APG]) Alexa Fluor 700 antibody (4 µl reagent / 100 µl of peripheral whole blood).