Anti-CD31 / PECAM-1 Monoclonal Antibody (Clone:MEM-05)
Produktgrößen
0.1 mg
£532,00
30-1171-0.1MG
Über dieses Produkt
- SKU:
- 30-1171
- Zusätzliche Namen:
- PECAM1
- translate.label.attr.clone:
- MEM-05
- Klonalität:
- Monoclonal
- Weitere Details:
- CD31 (platelet endothelial cell adhesion molecule-1; PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding; which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion; transendothelial migration; angiogenesis; apoptosis; negative regulation of immunoreceptor signaling; autoimmunity; macrophage phagocytosis; IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Leukocytes of patient suffering from LGL-type leukaemia
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php