Anti-Lck Monoclonal Antibody (Clone:LCK-01)
Produktgrößen
0.1 mg
£561,00
30-1170-0.1MG
Über dieses Produkt
- SKU:
- 30-1170
- Zusätzliche Namen:
- LCK
- translate.label.attr.clone:
- LCK-01
- Klonalität:
- Monoclonal
- Weitere Details:
- Lck is a Src-family tyrosine kinase; which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering; Lck phosphorylates the ITAM motives in its zeta subunits; establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70; which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane; there is also a significant fraction associated with the Golgi apparatus; which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli; but not by the death receptors.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Peptide corresponding to amino acids 22-36 in the sequence of human Lck.
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg