Anti-CD25 / IL-2R alpha chain Monoclonal Antibody (Clone:MEM-181) PerCP-Cy™5.5 Conjugated
Produktgrößen
100 tests
£700,00
30-1123-PerCP-Cy5.5-100TESTS
Über dieses Produkt
- SKU:
- 30-1123-PerCP-Cy5.5
- Zusätzliche Namen:
- IL2RA
- translate.label.attr.clone:
- MEM-181
- Klonalität:
- Monoclonal
- Weitere Details:
- Specificity: The antibody MEM-181 reacts with an extracellular epitope of CD25 (Interleukin-2 receptor alpha chain); a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes; activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes. Description: CD25 (IL2Ralpha; Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R; whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac; whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction; and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas.
- Host:
- Mouse
- Immunogen:
- PHA-activated peripheral blood leucocytes
- Isotyp:
- Mouse IgG1
- Aufreinigung:
- Purified antibody is conjugated with activated tandem dye of activated Peridinin-Chlorophyll Protein-Cyanine 5.5 (PerCP-Cy™5.5) under optimum conditions and unconjugated antibody and free fluorochrome
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:Image 1.jpg
