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Antikörper

Alexa Fluor 700 Conjugated Anti-Human CD30 Monoclonal Antibody(Clone: MEM-268)

Produktgrößen
100 tests
£642,00
30-1073AF700-100TESTS
Über dieses Produkt
SKU:
30-1073AF700
Zusätzliche Namen:
Ki-1; TNFRSF8; CD30L receptor; D1S166E
translate.label.attr.clone:
MEM-268
Klonalität:
Monoclonal
Weitere Details:
CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation; activation; differentiation; and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells; CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas); virus-infected T and B cells; and on normal T and B cells after activation. In T cells; CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response Specificity: The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen); a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells; it is also found in Burkitt's lymphomas; virus-infected T and B lymphocytes; and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Host:
Mouse
Immunogen:
Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
Isotyp:
Mouse IgG2a kappa
Aufreinigung:
Purified antibody is conjugated with Alexa Fluor 700 NHS ester under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Separation of human CD30 positive cells (red-filled) from human CD30 negative cells (black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral blood mononuclear cells stained using anti-human CD30 (MEM-268) Alexa Fluor 700 antibody (4 μl reagent per milion cells in 100 μl of cell suspension).
Figure 2: Separation of human CD30 positive cells (red-filled) from human CD30 negative cells (black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral blood mononuclear cells stained using anti-human CD30 (MEM-268) Alexa Fluor 700 antibody (4 μl reagent per milion cells in 100 μl of cell suspension).