APC Conjugated Anti-CD30 Monoclonal Antibody (Clone:Ber-H8)
Produktgrößen
100 tests
£649,00
30-1073AC-100TESTS
Über dieses Produkt
- SKU:
- 30-1073AC
- Zusätzliche Namen:
- Ki-1; TNFRSF8; CD30L receptor; D1S166E
- translate.label.attr.clone:
- Ber-H8
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Weitere Details:
- CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation; activation; differentiation; and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells; CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas); virus-infected T and B cells; and on normal T and B cells after activation. In T cells; CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. Specificity: The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen); a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells; it is also found in Burkitt's lymphomas; virus-infected T and B lymphocytes; and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
- Host:
- Mouse
- Isotyp:
- Mouse IgG1 kappa
- Aufreinigung:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg