Anti-CD4 Monoclonal Antibody (Clone:MEM-115)-Azide free
Produktgrößen
0.1 mg
£532,00
30-1001-0.1MG
Über dieses Produkt
- SKU:
- 30-1001
- Zusätzliche Namen:
- CD4
- translate.label.attr.clone:
- MEM-115
- Klonalität:
- Monoclonal
- Weitere Details:
- CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa; cytoplasmic tail consists of 38 aa. Domains 1;2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck; a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains.Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3); Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1); L-selectin Intracellular ligands: p56LckCD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation; T/B-cell adhesion; T-cell diferentiation; T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood; tissue and organs (SCID immunodeficiency).
- Host:
- Mouse
- Immunogen:
- Human thymocytes and T lymphocytes.
- Isotyp:
- Mouse IgG2a
- Aufreinigung:
- Purified by protein-A affinity chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:30-1001 FLOW.jpg
