Recombinant Human ACE2 Fc Protein expressed in CHO-K1
Produktgrößen
50µg
£436,00
21-1007-50UG
100µg
£606,00
21-1007-100UG
500µg
£1926,00
21-1007-500UG
Über dieses Produkt
- SKU:
- 21-1007
- Zusätzliche Namen:
- Alternative name Human ACE2 Protein; Recombinant Human ACE2; Human Recombinant ACE-2; Angiotensin-converting enzyme 2
- Weitere Details:
- Source: CHO-K1. Recombinant Human ACE2- Fc protein is produced in CHO-K1. Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE; and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9; a peptide of unknown function; and angiotensin II to angiotensin 1-7; a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung; gut; heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus; 2019-nCoV/SARS-CoV-2; which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infection.
- Aufreinigung:
- >95% by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Human ACE2 Fc Recombinant Protein is shipped on ice packs. Upon arrival; Store at -20[o]C. Do not freeze-thaw multiple times.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:binding-of-ace2-with-rbd-fc.jpg