Polyclonal antibody to NOD2 (Card15)
Produktgrößen
50 µl
£396,00
20-1115-50UL
Über dieses Produkt
- SKU:
- 20-1115
- Zusätzliche Namen:
- NOD2||CARD15||IBD1
- Klonalität:
- Polyclonal
- Weitere Details:
- Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome; and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways; thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria; the induction of inflammatory responses; and the regulation of caspase activation and apoptosis. NOD2/CARD15 is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006; and Inohara et al. 2003). NOD2 is expressed in cells that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells; and epithelial cells (reviewed in Strober et al. 2006). NOD2 is thought to play a role in the pathogenesis of human gastrointestinal disease. Polymorphisms and mutations in NOD2 are associated with susceptibility to Crohn's disease; a chronic inflammatory bowel disease (Leung et al.; 2006). Additionally; polymorphisms in NOD2 have also been found to be associated with Graft-versus-Host Disease (GVHD) (Holler et al.; 2004).This association of NOD2 gene polymorphisms with gastrointestinal disease and GVHD suggests that NOD2 gene polymorphisms play a role in pro-inflammatory diseases. This antibody recognizes NOD2; a 1040 amino acid protein. This antibody also recognizes NOD2 alternatively spliced and mutated forms which contain the peptide immunogen sequence including NOD2 short; a 273 amino acid protein.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human NOD2/CARD15 (amino acids 582-600 LGFLVRAKGVVPGSTAPLE) was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
