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Antikörper

Polyclonal antibody to CARD8 (Tucan)

Produktgrößen
50 µl
£396,00
20-1104-50UL
Über dieses Produkt
SKU:
20-1104
Zusätzliche Namen:
CARD8||KIAA0955||NDPP1
Klonalität:
Polyclonal
Weitere Details:
This antibody recognizes TUCAN; a 431 amino acid protein. TUCAN (tumor up-regulated CARD-containing antagonist of caspase nine) also known as CARD8 is a CARD domain containing protein. Proteins containing a CARD (caspase-associated recruitment domain) domain are key regulators of cell death; cell survival and cytokine production. TUCAN is an anti-apoptotic CARD protein that can protect tumors from cell death stimuli; and is overexpressed in certain forms of cancer. TUCAN has been shown to inhibit caspase-9 activation by binding to the CARD region of pro-caspase-9; thereby suppressing the formation of the Apaf-1-caspase-9 apoptotic complex and apoptosis. Additionally; a TUCAN isoform has been described that blocks both caspase-8 and caspase-9 mediated apoptosis. However; in some tumors; TUCAN play a role in modulating NFkB transcription factor survivial signaling pathways.
Format:
Sera
Host:
Rabbit
Immunogen:
Full-length recombinant protein of human TUCAN (CARD8) was used as immunogen for this antibody
Isotyp:
Rabbit IgG
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Polyclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig:2 Formalin-fixed; paraffin-embedded tissue human colon microarray stained for TUCAN/CARD8 expression at 1:2000 using 20-1104. A-A2; sucessively higher magnifications of the microarray. A; low magnification overview. A1; differential TUCAN/CARD8 staining between tissue cores is observed. A2; Areas of intense TUCAN/CARD8 staining in a colon carcinoma tissue core. Hematoxylin eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded tumor/normal adjacent tissue cores from a human colon tissue microarray stained for TUCAN/CARD8 expression at 1:2000 using 20-1104. A and B are tumor tissue cores. A1 and B1 are the matched normal adjacent cores from A and B; respectively. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded tumor/normal adjacent tissue cores from a human colon tissue microarray stained for TUCAN/CARD8 expression at 1:2000 using 20-1104. A and B are tumor tissue cores. A1 and B1 are the matched normal adjacent cores from A and B; respectively. Hematoxylin-eosin counterstain.