Polyclonal antibody to Mouse TRAF-2
Produktgrößen
50 µl
£396,00
20-1097-50UL
Über dieses Produkt
- SKU:
- 20-1097
- Zusätzliche Namen:
- E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2
- Klonalität:
- Polyclonal
- Weitere Details:
- This antibody recognizes TRAF2; which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro; TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation; as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1).
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of mouse TRAF-2 (amino acids 250-271 CSFLEAQASPGTLNQVGPELLQR) was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
