Polyclonal antibody to Survivin
Produktgrößen
50 µl
£396,00
20-1091-50UL
Über dieses Produkt
- SKU:
- 20-1091
- Zusätzliche Namen:
- birc5.1-a||bir1-A||svv1
- Klonalität:
- Polyclonal
- Weitere Details:
- Survivin is a member of the family of inhibitor of apoptosis proteins (IAP); and is involved in both the control of apoptosis and regulation of cell division. IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains.It is a 142 amino acid protein with an approximate molecular weight of 16.5 kDa. Structurally; survivin is composed of a single BIR domain and an extended COOH-terminal a-helical coiled-coil domain and is highly expressed in embryonic and fetal organs.Survivin is undetectable in most normal differentiated and non-proliferating tissues; but is highly expressed in majority of human tumor types including lung; breast; colon; gastric; leukemias; neuroblastoma; brain tumors; pheochromocytoma; soft tissue sarcomas; melanomas and other skin tumors. Additionally; survivin expression has also been detected in a variety of preneoplastic or benign leisons; suggesting that re-expression of survivin may occur early during malignant transformation or following a disruption in the balance between cell division and apoptosis.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A Full-length recombinant protein of human Survivin was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
