Polyclonal antibody to SMAC/Diablo
Produktgrößen
50 µl
£396,00
20-1088-50UL
Über dieses Produkt
- SKU:
- 20-1088
- Zusätzliche Namen:
- DIABLO||SMAC
- Klonalität:
- Polyclonal
- Weitere Details:
- Smac/DIABLO (second mitochondrial-derived activator of caspase/direct IAP binding protein with low pI) is encoded by the nucleus and resides as a precursor within the intermembranous space of the mitochondria. During apoptosis; Smac/DIABLO is proteolytically cleaved and released from the mitochondria into the cytosol; where it promotes cell death by interacting with IAPs and inhibiting their anti-apoptotic function. In turn; certain IAPs may degrade Smac/DIABLO and block its cell death function. Smac/DIABLO is expressed in a wide range of normal tissues and some tumor cells lines; and its over-expression in tumor cell lines can trigger both extrinsic and intrinsic apoptosis pathways.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A Full-length recombinant protein of human SMAC was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg