Polyclonal antibody to MALT-1 (Paracaspase)
Produktgrößen
50 µl
£396,00
20-1081-50UL
Über dieses Produkt
- SKU:
- 20-1081
- Zusätzliche Namen:
- MALT1||MLT
- Klonalität:
- Polyclonal
- Weitere Details:
- MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma. Human MALT1has two isoforms ; isoform a is an amino acid protein of 824 amino acids; and human MALT1 isoform b is an amino acid protein of 813 amino acids. MALT1 is a caspase-like protein that contains an N-terminal death domain; two Ig-like domains; and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB. MALT1 is thought to play an important role in NF-kappaB signaling by enchancing NF-kappaB activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK activation in vitro through facilitatiing the ubiquitination of NEMO by the ubiquitin-conjugating enzyme UBC13. Four recurrent chromosomal translocations have been described in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid issue (MALT) type. Translocations involving Bcl10 and MALT1 may lead to elevated NF-kappaB activity in MALT B-cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms and have been described for the MALT1 gene.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A recombinant protein fragment of human MALT1/Paracaspase was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
