Polyclonal antibody to NLRP2/NALP2 (PAN1)
Produktgrößen
50 µl
£396,00
20-1078-50UL
Über dieses Produkt
- SKU:
- 20-1078
- Zusätzliche Namen:
- NLRP2||NALP2||NBS1||PAN1||PYPAF2
- Klonalität:
- Polyclonal
- Weitere Details:
- NALP2 (also known as PAN1/PYPAF2) is a member of the NLR (NACHT-LRR) family which includes both NODs and NALPs. Whereas This antibody recognizes NALP2; which is a 1062 amino acid protein. Alternative names for the NLR family include CATERPILLER; NOD and NOD-LRR. NLR family members are thought to be intracellular pathogen-recognition receptors (PRRs). At least fourteen NALPs have been identified in the human genome; and a common feature among NALPs 1-3; 6; and 12 is their ability to recruit the adaptor protein ASC through a homotypic PYD-PYD interaction; which in turn recruits caspase-1 through a CARD-CARD interaction. The oligomerization of NALPs is thought to bring the inflammatory caspases into close proximity leading to their activation within the inflammasome. The NALP2/3 inflammasomes contain; in addition to NALP2 or NALP3; the caspase recruitment domain (CARD)-containing protein Cardinal; ASC and caspase 1. Processing of the pro-inflammatory cytokines IL-1b and IL-18 by caspases leads to to the secretion of active cytokines and elicits a potent inflammatory response. The expression of NALP2 is upregulated in THP-1 macrophage cells by LPS and certain cytokines including interferon g and b; supporting a role for NALP2 in host-defense and inflammation. Additionally; NALP2 is expressed in several human tumor cell lines. However; the endogenous expression of NALP2 varies widely among tumor cells lines; with the highest levels found in MCF-7 and MDA-MB-435 breast cancer; Caco2 colon cancer and UACC62 melanoma cells. This antibody recognizes NALP2; human NALP2 is a 1062 amino acid protein; it is specific for NALP2 does not cross-react with related family members PAN2 or NAC.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human NALP2 (amino acids 97-115 LKSFNKRKPLSLGITRKER) was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg