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Antikörper

Polyclonal antibody to FLIP

Produktgrößen
50 µl
£396,00
20-1065-50UL
Über dieses Produkt
SKU:
20-1065
Zusätzliche Namen:
CASH|| CASP8AP1||CLARP||MRIT
Klonalität:
Polyclonal
Weitere Details:
This antibody recognizes FLIP long and short; isoforms that contain the peptide immunogen sequence (DRKAVETHLLRNPHLVSD). Human FLIP is a 480 amino acid protein which contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10; and potently inhibits apoptosis induced by death receptors.However; the functions of FLIP remain to be fully elucidated and there is some evidence FLIP may also act as an activator of caspase-8/-10 in certain cases; thereby taking on an apoptosis promoting role.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the caspase (ICE/CED-3) protease family. Most if not all; forms of apoptosis involve activation of the caspases. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP; respectively. The human FLIP was also cloned by several labs independently and termed Casper ; I-FLICE; FLAME-1; CASH and CLARP3-7.
Format:
Sera
Host:
Rabbit
Immunogen:
A synthetic peptideof human FLIP (amino acids 75-92 DRKAVETHLLRNPHLVS) was used as immunogen for this antibody
Isotyp:
Rabbit IgG
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Polyclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig:2 Immunhohistochemical analysis of FLIP in tissues cores from a formalin-fixed; paraffin-embedded human brain tumor microarray using 20-1065 at 1:2000. A-C; tissue cores from a patient with gemistocytoma. A; normal adjacent brain tissue. Astrocytes are positive for Flip expression. B; gemistocytoma (Grade II). Gemistocytes are positive for Flip expression. C; peritumoural oedma brain tissue. Reactive astrocytocytes are positive for FLIP expression. C1; a higher magnification of C. Collectively; the data shows that astrocytes (normal); reactive astrocytes and gemistocytes are positive for Flip expression. Hematoxylin-eosin counterstain.
Fig:2 Immunhohistochemical analysis of FLIP in tissues cores from a formalin-fixed; paraffin-embedded human brain tumor microarray using 20-1065 at 1:2000. A-C; tissue cores from a patient with gemistocytoma. A; normal adjacent brain tissue. Astrocytes are positive for Flip expression. B; gemistocytoma (Grade II). Gemistocytes are positive for Flip expression. C; peritumoural oedma brain tissue. Reactive astrocytocytes are positive for FLIP expression. C1; a higher magnification of C. Collectively; the data shows that astrocytes (normal); reactive astrocytes and gemistocytes are positive for Flip expression. Hematoxylin-eosin counterstain.