Polyclonal antibody to PTPN13/PTPL1 (FAP1)
Produktgrößen
50 µl
£396,00
20-1064-50UL
Über dieses Produkt
- SKU:
- 20-1064
- Zusätzliche Namen:
- PTPN13||PNP1||PTP1E||PTPL1
- Klonalität:
- Polyclonal
- Weitere Details:
- This antibody recognizes FAP-1; including FAP-1 isoforms; FAP-1 (also known as Fas-associated phosphatase-1; PTPN13; PTP-BAS; hPTPIE; and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family FAP-1 phosphatase is thought to be important in the Fas signaling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1; CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general; FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas signal transductions. Additionally; FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human FAP-1 (amino acids 1760-1775 EPTRQENWTPLKNDLE) was used as immunogen for this antibody
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:download_pdf.php