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Antikörper

Polyclonal antibody to Caspase-9

Produktgrößen
50 µl
£396,00
20-1044-50UL
Über dieses Produkt
SKU:
20-1044
Zusätzliche Namen:
CASP9||MCH6
Klonalität:
Polyclonal
Weitere Details:
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6; Mch6; and Apaf-3. Caspase-9 and Apaf-1 bind to each other; which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases; being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha; TRAIL; anti-CD-95; FADD; and TRADD. Caspase-9 is expressed in a variety of human tissues. The Cleaved Caspase-9 polyclonal antibody preferntially recognizes (active) cleaved Caspase-9. Whereas the antibody has a strong preference for (active) cleaved Caspase-9; in some cell or tissue systems or techniques the antibody may also recognize the pro form of Caspase-9.
Format:
Sera
Host:
Rabbit
Immunogen:
A recombinant catalytically active of human Caspase-9 protein was used as the immunogen for this antibody
Isotyp:
Rabbit IgG
Reaktivitäten:
Human, Mouse, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Polyclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig:2 Formalin-fixed; paraffin-embedded dog brain sections stained for cleaved Caspase-9 expression using 20-1044 antibody at 1:2000. A. Section from a dog brain 2 hr after reperfusion injury. B. Section from a dog brain sham control (brain surgery but no injury). Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded human brain sections stained for cleaved Caspase-9 expression using 20-1044 antibody at 1:2000. A. Section from a patient 24 hr after head trauma. B. Control: section from a patient with no known neurological disease or head injury. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded human brain sections stained for cleaved Caspase-9 expression using 20-1044 antibody at 1:2000. A. Section from a patient 24 hr after head trauma. B. Control: section from a patient with no known neurological disease or head injury. Hematoxylin-eosin counterstain.